Yes, but it affects the way how you design your applications and frameworks. In image-based setup you tend to do things in a way, that things should be always available at any moment (wanna create an instance of me? - feel free to do it).
In C and other languages which having compile& run cycle it is totally different. Things are available for you not instantly, but only after you restart everything from scratch, reinitialize everything and then repeat exactly same steps to meet the same point as before. This is often tedious, time consuming and frustrating.
And this difference in approaches leads to fatal flaws in design, like on Windows OS, which requires you to reboot machine every time you install new driver(s) Ok, I do agree on that. It's probably not an intrinsic flaw of the system, it just makes you think differently. However, suppose that C would have a REPL which gives you an inspector... then you'd already be more inclined to build systems like Smalltalk has. I don't say Smalltalk and its philosophy isn't great, I'm just saying that the image isn't a requirement. I'm sure that if someone would build a more flexible version of C that people would get used to it and want nothing else... even expect it.
But whatever :)