One of my experiments of testing my Pharo to Python bridge (What I have named project "Atlas") was to  build a QT hello world example. It created a problem because I was using python threads that QT does not like (it offers its own kind of threads) but after changing the code to use no threads, it worked. 

My bridge is not like UFFI where anything has to be wrapped because unlike C , Python is a dynamic language so there is no need for wrappers because Atlas allows dynamic execution of code. But of course there is the issues of data types and how they can be mapped to Pharo and the fact that PyQT free version is GPL and commercial is 500 dollars which sits of course on top of the commercial version of QT. So at the time I decided to not pursue it. 

I will give it a try and see how far it can goes, at worst I may offer a partial solution to using QT with Pharo. Then someone else can take it from there if there is genuine interest and expand it to more features.